منابع مشابه
Healthy goats naturally devoid of prion protein
Prion diseases such as scrapie in small ruminants, bovine spongiform encephalopathy (BSE) in cattle and Creutzfeldt-Jakob disease (CJD) in man, are fatal neurodegenerative disorders. These diseases result from the accumulation of misfolded conformers of the host-encoded prion protein (PrP) in the central nervous system. To date naturally-occurring PrP free animals have not been reported. Here w...
متن کاملNaturally Resistant Human Cells
Replication of virus can take place in naturally resistant cells, provided that measures are taken to circumvent the barrier to infection presented at the cell surface. Holland and his associates (9) initiated infection in resistant chick embryo cells with poliovirus ribonucleic acid (RNA). Subsequently Enders and his co-workers (4) and Neff and Enders (11) showed that complete poliovirus repli...
متن کاملPrion-resistant or prion-susceptible species, this is the question
Previous in vivo studies left the scientific community with the assumption that rabbits were resistant to prion diseases. However, our recent findings proved they are susceptible. The in vitro results were essential to demonstrate that prion protein (PrP) from every species has the potential to become not only misfolded to a disease associated form, but also capable of being virulent and causin...
متن کاملPrion Peptide Uptake in Microglial Cells – The Effect of Naturally Occurring Autoantibodies against Prion Protein
In prion disease, a profound microglial activation that precedes neurodegeneration has been observed in the CNS. It is still not fully elucidated whether microglial activation has beneficial effects in terms of prion clearance or whether microglial cells have a mainly detrimental function through the release of pro-inflammatory cytokines. To date, no disease-modifying therapy exists. Several im...
متن کاملPrion strains in mammals: Different conformations leading to disease
Prion diseases are neurodegenerative disorders affecting mammals with a diverse etiology. Although rare, most of the cases occur spontaneously in humans, with a minority being inherited or acquired by infection. Prion disease in ruminants such as sheep, goat, and deer are relatively frequent and likely feed borne [1] or environmentally transmitted [2]. The confirmed zoonotic potential of bovine...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Prion
سال: 2012
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.22057